Posts Tagged ‘chronic non-malignant pain (CNMP)’

Pain meds Part IV: Finis

Thursday, January 3rd, 2013

Some pain pills come the legal way

I'm finally going to end this four-part series of posts on pain medications, their relatives and the issues with the "normal" prescription variety. Today I'm writing about legal drugs, used to control acute pain, chronic cancer-related pain (CCRP) and often for chronic non-malignant pain (CNMP). Of course they're also used for illegal purposes...frequently.

My series began to expand when I read an article in The Wall Street Journal in mid-December titled "A Pain-Drug Champion Has Second Thoughts."  It told how Dr. Russell Portenoy, a New York academic pain specialist, Professor of Neurology at the Albert Einstein College of Medicine, trustee of the American Board of Hospice and Palliative Medicine and a past president of the American Pain Society has switched his point of view on pain pills for CNMP.

Twenty years ago he spear-headed the movement to both help those with chronic pain and to advocate the use of opioids that many physicians avoided, fearing their addictive properties. Those would include drugs such as OxyContin, Percocet  and Vicodin (which a federal advisory panel recommended be banned in 2009), each of which rose to the top ranks of widely prescribed drugs. The opioids, when combined with over-the-counter pain medicine (e.g., aspirin, ibuprofen or acetaminophen) are in a less controlled status than the parent drug alone.

As far back as 1998 one prominent pain specialist urged be put higher on the controlled substance list which has a hierarchy from Schedule I  (authorized for research only) to Schedule 5  (e.g., narcotic-containing cough meds). What's the difference?  If a drug is in Schedule II it requires a manually signed prescription with no refills, whereas Schedule III drugs can be called in to a pharmacy for refills.According to the DEA, a Schedule II drug has a 30-day prescription length and one needs a new prescription for refills; Schedule III and IV drugs have no mandatory controls on length of prescription (insurers may limit), and one can receive five refills in six months.

Neonatal ICUs often have newborns from addicted mothers

As "Pain Pill Mills" spread widely across America people began to have second thoughts. An article from the WSJ six days ago told the story of "Pain Pills' Littlest Victims," babies born to mothers addicted to drugs such as oxycodone. These infants have withdrawal symptoms, require intensive care and typically cost Medicaid over $50,000. In 2009 there were over 13,000 of such newborns, requiring $720 million of hospital care. Hospitals have been ill-prepared for their care and had no fixed protocols for what is termed "neonatal abstinence syndrome." These newborns may be delivered to moms who have taken a variety of drugs: amphetamines, barbiturates; cocaine, benzodiazepines as well as opiates. Their care needs depend on what drug, how much and how long it's been used, how the mother's body metabolizes it and whether the baby was born prematurely. States including Florida, West Virginia and Kentucky have had considerable numbers of these afflicted newborns with hospitals in an area north of Tampa reporting up to 30% of their NICU patients treated for withdrawl from opioids.

Florida passed a law stating only doctors can operate pain clinics, so some owners have moved to other states without such restrictions. Deaths from two of the most commonly used opioids have decreased in Florida since the law went into effect, but Georgia's rules aren't as strict so a former used-car dealer from Florida opened a pain clinic there in 2010, hired two physicians through Craig's List and soon was dispensing RXs to 50 patients a day. Georgia had 10 such pill mills in 2010 and 125 in late 2012.

Overall accidental deaths from heroin overdoses increased slightly during the 2000 to 2009 time frame and cocaine-related deaths fell; both are under the 5,000 per year mark. But fatalities from painkillers increased markedly during the same period, to over 15,000 per year. A WSJ article published online Dec. 5, 2012 told the story of a 23-year-old woman who was one such casualty. Drug overdoses are now the most common cause of US accidental deaths, passing traffic-related casualties in 2009.

Our country spends roughly $15B per year combating illegal drug trafficking, mostly concentrating on other countries. It's time and past time to fight the pain pill problem here at home.

Pain Pills and their ugly cousin: Part 1

Thursday, December 20th, 2012

I had a total knee replacement nearly twelve years ago. On the Orthopedic ward I was told I could have one or two strong pain pills every 4 to 12 hours depending on how much pain I was experiencing. Since I have a fairly high pain threshold I decided to take the minimum dose, one every twelve hours. I took the first pill, felt considerable relief from the pain, but also felt strange, so I stayed at that dose.

One way to flex & extend after a total knee replacement

Then I ran into a snag. My release from the hospital depended on the degree of flexion I could achieve in the leg with the new knee. Several times a day I was hooked up to a device that gradually bent my leg. It really hurt, but I toughed it out. The nurses and the physical therapists (PT) didn't seem to communicate with each other and I was a bit slow to catch on.

"You're not making enough progress," my surgeon said. "I think we'll have to extend your stay."

Something finally clicked in my mind. I was hurting enough so the ward staff hadn't set the machines degree of flexion higher. I decided to take two of the pain pills an hour or so before the PT appeared to check my ability to have the leg bent passively.

This time I was in no pain, although I did feel weird.

"You're doing much better today," she said. "I'll tell your doc you can go home tomorrow."

I had been given a strong pain pill, probably oxycodone and they were going to give me a prescription for several weeks worth to take at home. I asked, "Can I have extra strength Tylenol instead?" I repeated that request when I had low back surgery six months later.

Since that time there's been considerable controversy about strong pain medications. The initial question was whether physicians were under-prescribing for patients with severe pain, usually cancer-related, in fear of getting them "hooked" on the drug. Subsequently there have been at least two tidal shifts in how pain medicines are viewed, one urging more treatment of pain including giving the most potent meds for chronic non-malignant pain (CNMP) as well as for cancer patents (who clearly needed to have adequate pain control and weren't always getting it).

Very recently there's been a re-evaluation of the trend. I want to go back to the basics and then follow the timeline of expert opinion that's been expressed on the subject in the last two hundred years. But I'll begin much further back than that.

A 2008 article now available online and authored by staff from the National Development and Research Institutes and from the Department of Pain Medicine and Palliative Care at New York City's Beth Israel Hospital explored the treatment of chronic pain in depth. A few comments from that article surprised me.

a field of opium poppies

In Mesopotamia, nearly 5,500 years ago, Sumerian farmers cultivated a plant called Hul Gil which translates as the "joy plant." We call it the opium poppy. An August 2002 PBS special titled "Bitter Harvest" walks through how this plant is processed into the highly potent street drug, heroin, with at that time 13 million addicts worldwide The United Nations Office on Drugs and Crimes (UNODC) has a 2009 paper online estimating similar numbers. The major alklaloid (a usually colorless, complex and bitter organic chemical) in opium  was isolated in 1903 and named morphine (the Greek god of dreams was Morpheus). Then the Bayer company made a chemical from morphine and gave it the brand name Heroin.

Nowadays much of the world's crop of opium poppies is grown in Afghanistan. The 2009 estimate from UNODC was for $60 billion of the worldwide total of $68 billion.

But I've strayed away from my theme, which isn't street drugs, but prescription medications, so I'll stop here and get back to the synthetic opiods in my next post..